Diabetes, even newly defined by HbA1c testing, is associated with an increased risk of in-hospital death in adults with COVID-19

Abstract Background Diabetes is associated with poor coronavirus disease 2019 (COVID-19) outcomes. However, little known on the impact of undiagnosed diabetes in COVID-19 population. We investigated whether diabetes, particularly was an increased risk death from COVID-19. Methods This retrospective study identified adult patients admitted to Tongji Hospital (Wuhan) January 28 April 4, 2020. determined using patients’ past history (diagnosed) or newly defined if hemoglobin A1c (HbA1c) level at admission ?6.5% (48 mmol/mol) (undiagnosed). The in-hospital mortality rate and survival probability were compared between non-diabetes (overall, diagnosed, diabetes) groups. Risk factors explored Cox regression analysis. Results Of 373 patients, 233 included final analysis, among whom 80 (34.3%) had diabetes: 44 (55.0%) reported a history, 36 (45.0%) as having by HbA1c testing admission. Compared group, overall group significantly (22.5% vs. 5.9%, p < 0.001). Moreover, overall, groups displayed lower Kaplan-Meier analysis (all 0.01). Using multivariate regression, age, quick sequential organ failure assessment score, D-dimer ?1.0 ?g/mL independent for Conclusions prevalence pre-existing high China. Diabetes, even admission, Screening measurement should be considered Chinese inpatients